If you are having trouble getting a mobile device to connect to your PC with ActiveSync, one of these articles might be helpful. I was especially surprised to see the note about Windows Live Once Care interferring with the USB connection.
Why isn't Windows Mobile connecting to my PC?Note that Windows Live Once Care can interfere with the USB connection to your PC.
ActiveSync USB connection troubleshooting guideThis topic also applies to ActiveSync 4.5
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Disclaimer The opinions expressed herein are my own personal opinions and do not represent my employer's view in any way.